GEIRA: gene-environment and gene–gene interaction research application
نویسندگان
چکیده
منابع مشابه
Candidate gene-environment interaction research: reflections and recommendations.
Studying how genetic predispositions come together with environmental factors to contribute to complex behavioral outcomes has great potential for advancing the understanding of the development of psychopathology. It represents a clear theoretical advance over studying these factors in isolation. However, research at the intersection of multiple fields creates many challenges. We review several...
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Background—Particulate air pollution has been associated with cardiovascular mortality and morbidity. Transition metals such as iron bound to the particles may be responsible for those associations. The protein product of the hemochromatosis (HFE) gene modulates uptake of iron and divalent cations from pulmonary sources and reduces their toxicity. Two HFE polymorphisms (C282Y and H63D) associat...
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Historically in plant breeding a large number of statistical models has been developed and used for studying genotype × environment interaction. These models have helped plant breeders to assess the stability of economically important traits and to predict the performance of newly developed genotypes evaluated under varying environmental conditions. In the last decade, the use of relatively low...
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The effects of genetic variants on phenotypic traits often depend on environmental and physiological conditions, but such gene-environment interactions are poorly understood. Recently developed approaches that treat transcript abundances of thousands of genes as quantitative traits offer the opportunity to broadly characterize the architecture of gene-environment interactions. We examined the g...
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There has been a massive delay in the age at first birth across Europe since 1970, which is now between 28-29 years (Mills et al. 2011). A primary reason for fertility postponement is the clash between the optimal biological period for women to have children with obtaining a higher education and building a career (Rindfuss et al. 1996; Brewster & Rindfuss 2000; Mills et al. 2011). The ability t...
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ژورنال
عنوان ژورنال: European Journal of Epidemiology
سال: 2011
ISSN: 0393-2990,1573-7284
DOI: 10.1007/s10654-011-9582-5